Anti-EFS monoclonal antibody (DCABH-11367) Made to order

Rabbit anti-Human EFS monoclonal antibody for WB, ELISA

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human EFS is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
EFS; embryonal Fyn-associated substrate; Cas scaffolding protein family member 3; CASS3; EFS1; EFS2
Entrez Gene ID
UniProt ID

Product Background


Gene summary
EFS (Embryonal Fyn-Associated Substrate) is a Protein Coding gene. Diseases associated with EFS include mitral valve insufficiency and anteroseptal myocardial infarction. GO annotations related to this gene include protein domain specific binding and SH3 domain binding. An important paralog of this gene is NEDD9. The longest protein isoform encoded by this gene contains an SH3 domain, which is known to be important in intracellular signal transduction. The protein encoded by a similiar gene in mice was shown to bind to SH3 domains of protein-tyrosine kinases. The function of this gene is unknown. Three alternatively spliced variants encoding different isoforms have been described for this gene.
Antigen Description
The protein encoded by this gene contains a SH3 domain, which is known to be important in intracellular signal transduction. The protein encoded by a similiar gene in mice was shown to be able to bind to SH3 domain of protein-tyrosine kinases. The function of this gene is unknown. Two alternatively spliced variants have been described. Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES (By similarity). The function about EFS antigen include SH3 domain binding; protein domain specific binding.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Xia, XH; Li, WY; et al. Silica-coated dimers of silver nanospheres as surface-enhanced Raman scattering tags for imaging cancer cells. INTERFACE FOCUS 3:-(2013).
Ishino, M; Ohba, T; et al. Identification of an Efs isoform that lacks the SH3 domain and chromosomal mapping of human Efs. ONCOGENE 15:1741-1745(1997).

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