Anti-eEF1E1 monoclonal antibody (DCABH-11361) Made to order

Rabbit anti-Human eEF1E1 monoclonal antibody for WB, ELISA

View other eEF1E1 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human EEF1E1 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
EEF1E1; eukaryotic translation elongation factor 1 epsilon 1; P18; eukaryotic translation elongation factor 1 epsilon-1; AIMP3; aminoacyl tRNA synthetase complex interacting multifunctional protein 3
Entrez Gene ID
UniProt ID

Product Background


Gene summary
EEF1E1 (Eukaryotic Translation Elongation Factor 1 Epsilon 1) is a Protein Coding gene. Among its related pathways are Gene Expression and Metabolism. An important paralog of this gene is EEF1E1-BLOC1S5. This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2.
Antigen Description
This gene encodes a multifunctional protein that localizes both in the cytoplasm and in the nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage and plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Positive modulator of ATM response to DNA damage. Eukaryotic translation elongation factor 1 epsilon-1 is a protein that in humans is encoded by the EEF1E1 gene.
Pathway
Cytosolic tRNA aminoacylation, organism-specific biosystem; Gene Expression, organism-specific biosystem; tRNA Aminoacylation, organism-specific biosystem.

Citations


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References


Zobel-Thropp, P; Yang, MC; et al. A novel post-translational modification of yeast elongation factor 1A - Methylesterification at the C terminus. JOURNAL OF BIOLOGICAL CHEMISTRY 275:37150-37158(2000).
Kim, MS; Jeong, EG; et al. Absence of somatic mutation of a tumor suppressor gene eukaryotic translation elongation factor 1, epsilon-1 (EEF1E1), in common human cancers. APMIS 116:832-833(2008).

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