Anti-EDEM2 monoclonal antibody, clone FQS25154-35

Antibody Isotype

IgG

Clone

FQS25154-35

Species Reactivity

Human

Immunogen

Recombinant fragment within Human C20orf31 aa 450 to the C-terminus. The exact sequence is proprietary.Database link: Q9BV94

Conjugate

Application Notes

WB: 1/1000 - 1/10000.

Alternative Names

EDEM2; ER degradation enhancer, mannosidase alpha-like 2; C20orf31, C20orf49, chromosome 20 open reading frame 31; ER degradation-enhancing alpha-mannosidase-like 2; bA4204.1; FLJ10783; ER degradation-enhancing-mannosidase-like protein 2; C20orf31; C20or

Entrez Gene ID

UniProt ID

Antigen Description

Involved in endoplasmic reticulum-associated degradation (ERAD) that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. It lacks mannosidase activity. Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle.

Pathway

Asparagine N-linked glycosylation, organism-specific biosystem; Calnexin/calreticulin cycle, organism-specific biosystem; ER Quality Control Compartment (ERQC), organism-specific biosystem; Metabolism of proteins, organism-specific biosystem; N-glycan trimming in the ER and Calnexin/Calreticulin cycle, organism-specific biosystem; Post-translational protein modification, organism-specific biosystem; Protein processing in endoplasmic reticulum, organism-specific biosystem;