Ectodysplasin R (EDAR) is a member of the TNF receptor superfamily (TNFRSF). The human and mouse EDAR homologs share 91% amino acid sequence identity. Within the TNFRSF, EDAR shares the highest similarities with XEDAR and TROY/TNFRSF19. EDA-A1 is the EDAR ligand.
Pathway
Cytokine-cytokine receptor interaction;
Citations
Publication ()
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References
Analysis of the canine EDAR gene and exclusion as a candidate for the hairless phenotype in the Chinese Crested dog
This is a first case report of a patient with hypohidrotic ectodermal dysplasia from Oman, who was found to carry a mutation in the EDAR gene after candidate gene selection based on regions of homozygosity in his genome.
COA
Publication 
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