Rabbit Anti-ECH1 Polyclonal antibody (DPABH-03790)

Rabbit Anti-Human ECH1 Polyclonal antibody for WB, IHC, IF, ELISA Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human, Mouse, Rat
Immunogen
ECH1 fusion protein, sequence: MAAGIVASRRLRDLLTRRLTGSNYPGLSISLRLTGSSAQEAASGVALGEAPDHSYESLRVTSAQKHVLHVQLNRPNKRNAMNKVFWREMVECFNKISRDADCRAVVISGAGKMFTAGIDLMDMASDILQPKGDDVARISWYLRDIITRYQETFNVIERCPKPVIAAVHGGCIGGGVDLVTACDIRYCAQDAFFQVKEVDVGLAADVGTLQRLPKVIGNQSLVNELAFTARKMMADEALGSGLVSRVFPDKEVMLDAALALAAEISSKSPVAVQSTKVNLLYSRDHSVAESLNYVASWNMSMLQTQDLVKSVQATTENKELKTVTFSKL (1-328aa encoded by BC017408)
Conjugate
unconjugated

Applications


Application Notes
WB: 1:500-1:2000
IHC: 1:20-1:200
IF: 1:10-1:100
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
ECH1; enoyl CoA hydratase 1, peroxisomal; HPXEL; delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial; dienoyl-CoA isomerase; peroxisomal enoyl-CoA hydratase 1
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ECH1 (Enoyl-CoA Hydratase 1, Peroxisomal) is a Protein Coding gene. Among its related pathways are Peroxisome and Fatty Acid Biosynthesis (WikiPathways). GO annotations related to this gene include receptor binding and isomerase activity. An important paralog of this gene is CDY1B. This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators.
Antigen Description
Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA. Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial is an enzyme that in humans is encoded by the ECH1 gene. 0The function about ECH1 antigen include isomerase activity; protein binding.

Citations


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References


Nagayoshi, Y; Ohba, T; et al. Characterization of 17 beta-hydroxysteroid dehydrogenase type 4 in human ovarian surface epithelial cells. MOLECULAR HUMAN REPRODUCTION 11:615-621(2005).
DieuaideNoubhani, M; Novikov, D; et al. Further characterization of the peroxisomal 3-hydroxyacyl-CoA dehydrogenases from rat liver - Relationship between the different dehydrogenases and evidence that fatty acids and the C-27 bile acids di- and tri-hydroxycoprostanic acids are metabolized by separate multifunctional proteins. EUROPEAN JOURNAL OF BIOCHEMISTRY 240:660-666(1996).

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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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