Interferon-beta differentially regulates expression of the IL-12 family members p35, p40, p19 and EB13 in activated human dendritic cells
JOURNAL OF NEUROIMMUNOLOGY
Authors: van Seventer, JM; Nagai, T; van Seventer, GA
Abstract
Interferon-beta is thought to provide clinical improvement to multiple sclerosis (MS) patients, in part, through its ability to suppress the generation of IL-12-dependent autoimmune T helper type 1 (Th 1) cells by monocyte-derived dendritic cells (DC). We now describe how preincubation with 1000 U/ml of IFN-beta differentially regulates expression of multiple IL-12 family members in activated, immature human DC, inhibiting CD40/IFN-gamma-induced p35 and p40 message levels, while enhancing p19 and Epstein-Barr virus-induced gene 3 (EBI3) levels. IFN-beta-mediated inhibition of p40 mRNA and augmentation of p 19 mRNA both require de novo protein synthesis. These findings indicate that IFN-beta will be found to have contrasting effects on DC secretion of the various IL-12 family homo- and heterodimers. (C) 2002 Elsevier Science B.V. All rights reserved.
The IL-23p19/EBI3 heterodimeric cytokine termed IL-39 remains a theoretical cytokine in man (vol 68, pg 423, 2019)
INFLAMMATION RESEARCH
Authors: Bridgewood, Charlie; Alase, Adewonuola; Watad, Abdulla; Wittmann, Miriam; Cuthbert, Richard; McGonagle, Dennis
Abstract
The original article can be found online.
COA
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