Anti-E2F6 (aa 268-281) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide: NPQQSEELLEVSN corresponding to C terminal amino acids 268 - 281 of Human E2F6, with a Cysteine residue linker (NP_937987.2).

Conjugate

Application Notes

WB: 1 - 3 μg/ml.

Alternative Names

E2F6; E2F transcription factor 6; transcription factor E2F6; E2F 6; E2F transcription factor 6, isoform 1; E2F-6; MGC111545;

Entrez Gene ID

UniProt ID

Antigen Description

Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5-TTTC[CG]CGC-3. Has a preference for the 5-TTTCCCGC-3 E2F recognition site. E2F-6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase.

Pathway

Cell cycle; E2F transcription factor network; G1 to S cell cycle control;