Anti-Chaoptin monoclonal antibody (DMAB9207)

Mouse anti-drosophila Chaoptin monoclonal antibody for WB, IHC Datasheet

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Host Species
Antibody Isotype
Species Reactivity
Drosophila melanogaster.


Alternative Names
Chp1; Wrch2
Entrez Gene ID
UniProt ID

Product Background

Antigen Description
Chaoptin is a photoreceptor cell-specific membrane protein. Analysis of chaoptin mutants demonstrates that this glycoprotein plays a critical role in photoreceptor cell morphogenesis. We have deduced chaoptin"s primary structure from the cDNA sequence and examined its membrane topology. Chaoptin is largely composed of 41 potentially amphipathic repeats. Remarkably homologous repeats have been reported in both yeast and human, suggesting their general importance as a structural and/or functional motif. Chaoptin synthesized in vitro is associated with rough endoplasmic reticulum microsomal membrane in an integral fashion, consistent with its extraction characteristics in vivo. The resistance to proteolytic digestion of in vitro synthesized and processed chaoptin suggests that it is primarily localized to the extracellular leaflet of the lipid bilayer. These data are consistent with the proposal that chaoptin is involved in the adhesion between photoreceptor cell membranes.


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Kawada, J; Wada, H; et al. Heteroclitic serological response in esophageal and prostate cancer patients after NY-ESO-1 protein vaccination. INTERNATIONAL JOURNAL OF CANCER 130:584-592(2012).
Park, IH; Youn, JH; et al. Anti-idiotypic antibody as a potential candidate vaccine for Neisseria meningitidis serogroup B. INFECTION AND IMMUNITY 73:6399-6406(2005).

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