Anti-Urokinase polyclonal antibody

Background: Prostate cancer is highly prevalent with a high mortality among males worldwide. Naringenin has been demonstrated to exhibit multiple cellular functions. In this study, we examined the effects of naringenin on prostate cancer. Materials and Methods: Transwell and zymography assays were used to detect cell migration and urokinase plasminogen activator (uPA) activity, respectively. Alternation of protein expression was measured by western blot analysis. Results: Transwell assay and zymography revealed that naringenin suppressed the migration and invasion of PC-3 cells and uPA activity in proportion to the concentration of naringenin. Western blot analysis indicated that naringenin up-regulated E-cadherin expression, but down-regulated the expression of vimentin, SNAIL family zinc finger 1 (SNAI1), SNAIL family zinc finger 2 (SNAI2), and TWIST family bHLH transcription factor 1 (TWIST1). Conclusion: Naringenin inhibited the migration and invasion of PC-3 cells by reversing expression of proteins involved in epithelial to mesenchymal transition and down-regulation of uPA activity. Thus, naringenin may be a promising anti metastasis agent for prostate cancer.

In millimeter-wave communications, full-dimension multiple-input multiple-output has been widely utilized to generate both horizontal and vertical beams by equipping uniform planar array (UPA) at the base station. However, considering the antenna radiation pattern for each sector, UPA offers nonuniform coverage in horizontal domain, where UEs on the boundary of each sector possess lower beamforming gains and hence the loss of spectral efficiency compared to the UEs at the center. In this paper, uniform cylindrical array (UCA) based hybrid precoding is proposed to improve the uniformity of beam coverage in horizontal domain and the fairness of spectral efficiency for UEs at different locations. Firstly, the UCA-based codebook is designed to generate uniform beams in horizontal domain. Next, the sector-free sub-connection transmitter architecture is designed to reduce the hardware complexity. Meanwhile, to serve multi-user transmission, the corresponding cyclic UE scheduling along with grouped digital precoding are introduced to suppress the inter-user interference. Theoretical analyses and simulation results demonstrate that the proposed scheme can improve the fairness of spectral efficiency compared to its conventional UPA counterpart.