Anti-DZIP1L (aa 459-543) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

antigen sequence: LEDTLEEKLE SMGIRKDAKG ISIQTLRHLE SLLRVQREQK ARKFSEFLSL RGKLVKEVTS RAKERQENGA VVSQPDGQPS VKSQQ, corresponding to amino acids 459-543 of Human DZIP1L.

Conjugate

Application Notes

IHC-P: 1/700. ICC/IF: 1 - 4 μg/ml.

Alternative Names

DZIP1L; DAZ interacting zinc finger protein 1-like; DZIP2; zinc finger protein DZIP1L; DAZ interacting protein 1-like; DAZ-interacting protein 1-like protein;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry.