Mouse anti-Human DUSP9 polyclonal antibody

Species Reactivity

Human

Immunogen

DUSP9 (NP_001386, 174 a.a. ~ 278 a.a) partial recombinant protein with GST tag. The sequence is AESEADRDSMSCGLDSEGATPPPVGLRASFPVQILPNLYLGSARDSANLESLAKLGIRYI LNVTPNLPNFFEKNGDFHYKQIPISDHWSQNLSRFFPEAIEFIDE

Conjugate

Alternative Names

DUSP9; dual specificity phosphatase 9; MKP4; MKP-4; dual specificity protein phosphatase 9; map kinase phosphatase 4; serine/threonine specific protein phosphatase; mitogen-activated protein kinase phosphatase 4;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases, is expressed only in placenta, kidney, and fetal liver, and is localized to the cytoplasm and nucleus.

Pathway

MAPK signaling pathway;