Anti-DTX2 (aa 454-503) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to a region within C terminal amino acids 454-503 (EDCGTILIVY SIPHGIQGPE HPNPGKPFTA RGFPRQCYLP DNAQGRKVLE) of Human DTX2(NP_001096066).

Conjugate

Application Notes

WB: 0.2 - 1 μg/ml.

Alternative Names

DTX2; deltex homolog 2 (Drosophila); deltex (Drosophila) homolog 2; protein deltex-2; RNF58; hDTX2; deltex2; ring finger protein 58; zinc ion binding protein; KIAA1528; MGC71098;

Entrez Gene ID

UniProt ID

Antigen Description

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.

Pathway

Activated NOTCH1 Transmits Signal to the Nucleus; Notch signaling pathway; Signal Transduction; Signaling by NOTCH; Signaling by NOTCH1;