Anti-DST (aa 401-500) polyclonal antibody

Species Reactivity

Human

Immunogen

DST (NP_899236, 401 a.a. ~ 500 a.a) partial recombinant protein with GST tag. The sequence is EDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQAD QLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMIS

Conjugate

Alternative Names

DST; dystonin; DT; BPA; DMH; BP240; BPAG1; EBSB2; HSAN6; MACF2; CATX15; CATX-15; D6S1101; trabeculin-beta; dystonia musculorum protein; bullous pemphigoid antigen 1; hemidesmosomal plaque protein;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the plakin protein family of adhesion junction plaque proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of some variants has not been defined. It has been reported that some isoforms are expressed in neural and muscle tissue, anchoring neural intermediate filaments to the actin cytoskeleton, and some isoforms are expressed in epithelial tissue, anchoring keratin-containing intermediate filaments to hemidesmosomes. Consistent with the expression, mice defective for this gene show skin blistering and neurodegeneration.

Pathway

Alpha6-Beta4 Integrin Signaling Pathway; Cell junction organization; Collagen formation; Type I hemidesmosome assembly.