This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Ozdemir, FN; Sezer, S; et al. Panel reactive antibody positivity and associated HLA antibodies in Turkish renal transplant candidates. TRANSPLANT IMMUNOLOGY 12:185-188(2004).
Myers, LK; Pihlajamaa, T; et al. Immunogenicity of recombinant type IX collagen in murine collagen-induced arthritis. ARTHRITIS AND RHEUMATISM 46:1086-1093(2002).
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