General Notes
This product (Catalog No. DPABH-28397) is a rabbit-derived IgG polyclonal antibody raised against human DPYSL4. It has been affinity purified by protein A. DPYSL4 (dihydropyrimidinase like 4) is a protein-coding gene in humans located on the long arm of chromosome 10 at position q26.3, encoding the dihydropyrimidinase-related protein 4 (CRMP3), a key member of the collapsin response mediator protein (CRMP) family. The gene spans approximately 19 kb, comprises 14 exons, and produces a 572-amino-acid protein with a conserved dihydropyrimidinase domain that facilitates cytoskeletal interactions. Primarily expressed in the brain, DPYSL4 plays an essential role in nervous system development, enabling filamin binding and mediating signaling by class 3 semaphorins to regulate axon guidance, neuronal growth cone collapse, and cytoskeleton remodeling; it also interacts with Tau protein in subtypes of Alzheimer's disease.
DPABH-28397 is suitable for use in Western blot (WB) (1:500–1:1,000), IHC (1:25–1:100) applications.
DPABH-28397 is supplied as a liquid formulation in pH7.4 PBS, 0.05% sodium azide, 40% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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