Anti-DPT monoclonal antibody (DCABH-11327) Made to order

Rabbit anti-Human DPT monoclonal antibody for WB, ELISA

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human DPT is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
DPT; dermatopontin; tyrosine-rich acidic matrix protein; TRAMP
Entrez Gene ID
UniProt ID

Product Background


Gene summary
DPT (Dermatopontin) is a Protein Coding gene. Diseases associated with DPT include leiomyoma and aniseikonia. Among its related pathways are TGF-beta Signaling Pathway (sino). Dermatopontin is an extracellular matrix protein with possible functions in cell-matrix interactions and matrix assembly. The protein is found in various tissues and many of its tyrosine residues are sulphated. Dermatopontin is postulated to modify the behavior of TGF-beta through interaction with decorin.
Antigen Description
Dermatopontin is an extracellular matrix protein with possible functions in cell-matrix interactions and matrix assembly. The protein is found in various tissues and many of its tyrosine residues are sulphated. Dermatopontin is postulated to modify the behavior of TGF-beta through interaction with decorin. Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity). Dermatopontin is a protein that in humans is encoded by the DPT gene. Dermatopontin is postulated to modify the behavior of TGF beta through interaction with decorin.

Citations


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References


Yamatoji, M; Kasamatsu, A; et al. Dermatopontin: A potential predictor for metastasis of human oral cancer. INTERNATIONAL JOURNAL OF CANCER 130:2903-2911(2012).
Fonseca, HEM; Chiba, AK; et al. Anti-N-like and anti-form red cell antibodies in chronic hemodialysis patients. RENAL FAILURE 26:553-556(2004).

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