Anti-DPPA3 monoclonal antibody (DCABH-11326) Made to order

Rabbit anti-Human DPPA3 monoclonal antibody for WB, ELISA

View other DPPA3 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human DPPA3 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
DPPA3; developmental pluripotency associated 3; developmental pluripotency-associated protein 3; Stella; stella-related protein; STELLA
Entrez Gene ID
UniProt ID

Product Background


Gene summary
DPPA3 (Developmental Pluripotency Associated 3) is a Protein Coding gene. GO annotations related to this gene include methylated histone binding. This gene encodes a protein that in mice may function as a maternal factor during the preimplantation stage of development. In mice, this gene may play a role in transcriptional repression, cell division, and maintenance of cell pluripotentiality. In humans, related intronless loci are located on chromosomes 14 and X.
Antigen Description
This gene encodes a protein that in mice may function as a maternal factor during the preimplantation stage of development. In mice, this gene may play a role in transcriptional repression, cell division, and maintenance of cell pluripotentiality. In humans, related intronless loci are located on chromosomes 14 and X. Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at Lys-9 (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis (By similarity). Developmental pluripotency-associated protein 3 is a protein that in humans is encoded by the DPPA3 gene.

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References


Ficz, G; Branco, MR; et al. Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation. NATURE 473:398-U589(2011).
Kol'tsova, AM; Gordeeva, OF; et al. Comparative Characteristics of New Human Embryonic Stem Cell Lines SC5, SC6, SC7, and SC3a. RUSSIAN JOURNAL OF DEVELOPMENTAL BIOLOGY 42:212-225(2011).

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