Anti-DPP8 monoclonal antibody (DCABH-11324) Made to order

Rabbit anti-Human DPP8 monoclonal antibody for WB, ELISA

View other DPP8 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human DPP8 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
DPP8; dipeptidyl-peptidase 8; dipeptidylpeptidase 8; dipeptidyl peptidase 8; dipeptidyl peptidase IV related protein 1; dipeptidyl peptidase VIII
Entrez Gene ID
UniProt ID

Product Background


Gene summary
DPP8 (Dipeptidyl Peptidase 8) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity and dipeptidyl-peptidase activity. An important paralog of this gene is DPP4. This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described.
Antigen Description
This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described. Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. May play a role in T-cell activation and immune function. Dipeptidyl peptidase 8 is an enzyme that in humans is encoded by the DPP8 gene. 0The function about DPP8 antigen include aminopeptidase activity; dipeptidyl-peptidase activity; peptidase activity; serine-type peptidase activity.

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References


Busek, P; Stremenova, J; et al. Dipeptidyl peptidase-IV enzymatic activity bearing molecules in human brain tumors - good or evil?. FRONTIERS IN BIOSCIENCE-LANDMARK 13:2319-2326(2008).
Busek, P; Stremenova, J; et al. Dipeptidyl peptidase-IV inhibits glioma cell growth independent of its enzymatic activity. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 44:738-747(2012).

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