DOCK7 functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. It does not have a GEF activity for CDC42. It is required for STMN1 Ser-15 phosphorylation during axon formation and consequently for neuronal polarization.
Pathway
ErbB2/ErbB3 signaling events; Factors involved in megakaryocyte development and platelet production; Hemostasis;
Citations
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