Anti-DOCK4 (aa 1867-1966) polyclonal antibody

Species Reactivity

Human

Immunogen

DOCK4 (NP_055520, 1867 a.a. ~ 1966 a.a) partial recombinant protein with GST tag. The sequence is NQVNEQSAPLPVPVPVPVPSYGGEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPVTS EPPALPPKPLAARSSHLENGARRTDPGPRPRPLPRKVSQL

Conjugate

Alternative Names

DOCK4; dedicator of cytokinesis 4; dedicator of cytokinesis protein 4;

Entrez Gene ID

UniProt ID

Antigen Description

This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized.

Pathway

Factors involved in megakaryocyte development and platelet production; Rap1 signaling pathway;