Specifications
Immunogen
Recombinant fragment corresponding to Human DOCK2 aa 1544-1830.Sequence: AKYEKAFFTEEYVRDHPEDQDKLTHLKDLIAWQIPFLGAGIKIHEKRVSD NLRPFHDRME ECFKNLKMKVEKEYGVREMPDFDDRRVGRPRSMLRSYRQMSIISLASMNS DCSTPSKPTS ESFDLELASPKTPRVEQEEPISPGSTLPEVKLRRSKKRTKRSSVVFADEK AAAESDL
Applications
Application Notes
WB: 1/2000; IHC-P: 1/150;
Target
Alternative Names
DOCK2; dedicator of cytokinesis 2; dedicator of cyto kinesis 2; dedicator of cytokinesis protein 2; KIAA0209; dedicator of cyto-kinesis 2; FLJ46592;
Product Background
Antigen Description
DOCK2 (dedicator of cytokinesis 2) is a hematopoietic cell-specific protein that participates in the cytoskeletal rearrangements required for lymphocyte migration in response to chemokines. DOCK2 activates the small GTPases RAC1 and RAC2 and may also be involved in IL2 transcriptional activation via the activation of RAC2.
Pathway
Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Disease, organism-specific biosystem; Factors involved in megakaryocyte development and platelet production, organism-specific biosystem; Fc gamma R-mediated phagocytosis, organism-specific biosystem; Fc gamma R-mediated phagocytosis, conserved biosystem; HIV Infection, organism-specific biosystem;
Citations
Publication ()
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COA
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