Mouse anti-Human DNASE2B polyclonal antibody

Species Reactivity

Human

Immunogen

DNASE2B (NP_067056, 258 a.a. ~ 357 a.a) partial recombinant protein with GST tag. The sequence is HLLTETWQRKRQELPSNCSLPYHVYNIKAIKLSRHSYFSSYQDHAKWCISQKGTKNRWTC IGDLNRSPHQAFRSGGFICTQNWQIYQAFQGLVLYYESCK

Conjugate

Alternative Names

DNASE2B; deoxyribonuclease II beta; DLAD; deoxyribonuclease-2-beta; DNase II beta; endonuclease DLAD; lysosomal DNase II; DNase2-like acid DNase; DNase II-like acid DNase;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene.

Pathway

Lysosome;