Anti-DMTF1 (aa 661-760) polyclonal antibody

Species Reactivity

Human

Immunogen

DMTF1 (NP_066968, 661 a.a. ~ 760 a.a) partial recombinant protein with GST tag. The sequence is KQEESPSDLASAYVTEGLESPTIEEQVDQTIDDETILIVPSPHGFIQASDVIDTESVLPL TTLTDPILQHHQEESNIIGSSLGSPVSEDSKDVEDLVNCH

Conjugate

Alternative Names

DMTF1; cyclin D binding myb-like transcription factor 1; DMP1; DMTF; MRUL; hDMP1; cyclin-D-binding Myb-like transcription factor 1; hDMTF1; cyclin D-binding Myb-like protein; cyclin-D-interacting Myb-like protein 1;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Pathway

Validated transcriptional targets of AP1 family members Fra1 and Fra2;