Specifications
Immunogen
A synthetic peptide of human DIS3 is used for rabbit immunization.
Target
Alternative Names
DIS3; DIS3 mitotic control homolog (S. cerevisiae); KIAA1008; exosome complex exonuclease RRP44; dis3p; EXOSC11; exosome component 11; RRP44; 2810028N01Rik; protein DIS3 homolog; ribosomal RNA-processing protein 44; mitotic control protein dis3 homolog; b
Product Background
Antigen Description
Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as anti-sense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities.
Pathway
Activation of Genes by ATF4, organism-specific biosystem; Deadenylation-dependent mRNA decay, organism-specific biosystem; Destabilization of mRNA by Butyrate Response Factor 1 (BRF1), organism-specific biosystem; Destabilization of mRNA by KSRP, organism
Citations
Publication ()
Have you cited DCABH-15179 in a publication?
Let us know and earn a reward for your research.
COA
Loading ......
