Anti-DHX38 monoclonal antibody, clone 4C0

Antibody Isotype

IgG2a

Clone

4C0

Species Reactivity

Human

Immunogen

DHX38 (NP_054722.2, 342 a.a. ~ 450 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

DHX38; DEAH (Asp-Glu-Ala-His) box polypeptide 38; DDX38, DEAD/H (Asp Glu Ala Asp/His) box polypeptide 38; pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; hPrp16; KIAA0224; PRP16; PRPF16; DEAH box protein 38; PRP16 homolog of S.cerevisiae; ATP-d

Entrez Gene ID

UniProt ID

Antigen Description

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD/H box family of splicing factors. This protein resembles yeast Prp16 more closely than other DEAD/H family members. It is an ATPase and essential for the catalytic step II in pre-mRNA splicing process.

Pathway

Cleavage of Growing Transcript in the Termination Region, organism-specific biosystem; Gene Expression, organism-specific biosystem; Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem; RNA Polymerase II Transcription, organism-specific biosystem; RNA Polymerase II Transcription Termination, organism-specific biosystem; Spliceosome, organism-specific biosystem; Spliceosome, conserved biosystem;