Anti-DHX30 monoclonal antibody (DCABH-11278) Made to order

Rabbit anti-Human DHX30 monoclonal antibody for WB, ELISA

View other DHX30 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human DHX30 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
DHX30; DEAH (Asp-Glu-Ala-His) box polypeptide 30; DDX30, DEAD/H (Asp Glu Ala Asp/His) box polypeptide 30; putative ATP-dependent RNA helicase DHX30; FLJ11214; KIAA0890
Entrez Gene ID
UniProt ID

Product Background


Gene summary
DHX30 (DEAH-Box Helicase 30) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and chromatin binding. An important paralog of this gene is DHX29. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The family member encoded by this gene is a mitochondrial nucleoid protein that associates with mitochondrial DNA. It has also been identified as a component of a transcriptional repressor complex that functions in retinal development, and it is required to optimize the function of the zinc-finger antiviral protein. Alternatively spliced transcript variants have been found for this gene.
Antigen Description
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The encoded protein has 97% sequence identity with the mouse HELG protein. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Plays an important role in the assembly of the mitochondrial large ribosomal subunit (PubMed:25683715). Required for optimal function of the zinc-finger antiviral protein ZC3HAV1 (By similarity). Associates with mitochondrial DNA (PubMed:18063578). The function about DHX30 antigen include ATP binding; ATP-dependent helicase activity; RNA binding; chromatin binding; helicase activity; hydrolase activity; nucleotide binding; protein binding.

Citations


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References


Minczuk, M; He, JY; et al. TEFM (c17orf42) is necessary for transcription of human mtDNA. NUCLEIC ACIDS RESEARCH 39:4284-4299(2011).
Wang, YS; Bogenhagen, DF; et al. Human mitochondrial DNA nucleoids are linked to protein folding machinery and metabolic enzymes at the mitochondrial inner membrane. JOURNAL OF BIOLOGICAL CHEMISTRY 281:25791-25802(2006).

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