DGKK (NP_001013764, 1171 a.a. ~ 1271 a.a) partial recombinant protein with GST tag. The sequence is AEDETALQSALDAMNKEFKKLSEIDWMNPIFVPEEKSSDTDSRSLRLKIKFPKLGKKKVE EERKPKSGQSVQSFIGNLWHRRHREDEAEGDDPLTPSRSQL
The protein encoded by this gene is an enzyme that phosphorylates diacylglycerol, converting it to phosphatidic acid. The encoded protein is a membrane protein and is inhibited by hydrogen peroxide. Variations in this gene have been associated with hypospadias.
Pathway
Effects of PIP2 hydrolysis; GPCR downstream signaling; Hemostasis; Signal Transduction
Citations
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