Anti-DDX6 monoclonal antibody (DCABH-5919) Knockout Validated

Rabbit anti-Human DDX6 monoclonal antibody for IHC-P, WB

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Clone
FQS23257
Species Reactivity
Mouse, Rat, Human
Immunogen
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human DDX6 aa 100-200 (Cysteine residue). The exact sequence is proprietary.Database link: P26196
Conjugate
Unconjugated

Applications


Application Notes
IHC-P: 1/100 - 1/250; WB: 1/1000 - 1/5000.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
DDX6; DEAD (Asp-Glu-Ala-Asp) box helicase 6; DEAD (Asp Glu Ala Asp) box polypeptide 6 , DEAD/H (Asp Glu Ala Asp/His) box polypeptide 6 (RNA helicase, 54kD) , HLR2; probable ATP-dependent RNA helicase DDX6; RCK; DEAD box-6
Entrez Gene ID
UniProt ID

Product Background


Gene summary
DDX6 (DEAD-Box Helicase 6) is a Protein Coding gene. Diseases associated with DDX6 include b-cell lymphomas. Among its related pathways are Gene Expression and Deadenylation-dependent mRNA decay. GO annotations related to this gene include nucleic acid binding and protein domain specific binding. This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Antigen Description
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis and cellular growth and division. In the process of mRNA degradation, DDX6 may play a role in mRNA decapping. It forms a complex with DCP1A, DCP2, EDC3 and EDC4/HEDLS. Note=A chromosomal aberration involving DDX6 may be a cause of hematopoietic tumors such as B-cell lymphomas. Translocation t(11;14)(q23;q32). Probable ATP-dependent RNA helicase DDX6 is an enzyme that in humans is encoded by the DDX6 gene. 0The function about DDX6 antigen include ATP binding; ATP-dependent helicase activity; RNA binding; RNA helicase activity; helicase activity; hydrolase activity; nucleic acid binding; nucleotide binding; protein binding.
Pathway
Deadenylation-dependent mRNA decay, organism-specific biosystem; Decapping complex, organism-specific biosystem; Decapping complex, conserved biosystem; Gene Expression, organism-specific biosystem; RNA degradation, organism-specific biosystem; RNA degradation, conserved biosystem; mRNA Decay by 5 to 3 Exoribonuclease, organism-specific biosystem.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Ando, Y; Nakamura, K; et al. Bacillus subtilis DEAD protein YdbR possesses ATPase, RNA binding, and RNA unwinding activities. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 70:1606-1615(2006).
Anel, AMD; Rossi, MS; et al. mRNA encoding a putative RNA helicase of the DEAD-box gene family is up-regulated in trypomastigotes of Trypanosoma cruzi. JOURNAL OF EUKARYOTIC MICROBIOLOGY 47:555-560(2000).

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