Anti-DDX46 monoclonal antibody (DCABH-11251) Made to order

Rabbit anti-Human DDX46 monoclonal antibody for WB, ELISA

View other DDX46 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human DDX46 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
DDX46; DEAD (Asp-Glu-Ala-Asp) box polypeptide 46; probable ATP-dependent RNA helicase DDX46; FLJ25329; KIAA0801; Prp5
Entrez Gene ID
UniProt ID

Product Background


Gene summary
DDX46 (DEAD-Box Helicase 46) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and ATP-dependent RNA helicase activity. This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the 17S U2 snRNP complex; it plays an important role in pre-mRNA splicing. Multiple alternatively spliced transcript variants have been found for this gene.
Antigen Description
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the 17S U2 snRNP complex; it plays an important role in pre-mRNA splicing. Plays an essential role in splicing, either prior to, or during splicing A complex formation. Probable ATP-dependent RNA helicase DDX46 is an enzyme that in humans is encoded by the DDX46 gene. The function about DDX46 antigen include ATP binding; ATP-dependent helicase activity; RNA binding; helicase activity; hydrolase activity; nucleotide binding.
Pathway
Spliceosome, organism-specific biosystem; Spliceosome, conserved biosystem.

Citations


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References


Miyado, M; Nakamura, M; et al. Mamld1 Deficiency Significantly Reduces mRNA Expression Levels of Multiple Genes Expressed in Mouse Fetal Leydig Cells but Permits Normal Genital and Reproductive Development. ENDOCRINOLOGY 153:6033-6040(2012).

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