Anti-DDIT3 monoclonal antibody, clone 674DU3.5.2

Antibody Isotype

IgM

Clone

674DU3.5.2

Species Reactivity

Human

Conjugate

Application Notes

WB: 1:500-1600

Alternative Names

DDIT3; CHOP; CHOP10; GADD153; DNA damage-inducible transcript 3 protein; C/EBP-homologous protein; C/EBP-homologous protein 10; Growth arrest and DNA damage-inducible protein GADD153

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.

Pathway

ATF-2 transcription factor network; Activation of Chaperone Genes by ATF6-alpha; Activation of Chaperones by ATF6-alpha; Activation of Genes by ATF4; Adipogenesis; MAPK signaling pathway; Metabolism of proteins; Non-alcoholic fatty liver disease (NAFLD);