Anti-DCTN3 monoclonal antibody, clone FQS6008

Antibody Isotype

IgG

Clone

FQS6008

Species Reactivity

Human

Conjugate

Application Notes

WB: 1:1,000 - 10,000; IHC: 1:100 - 250

Alternative Names

DCTN3; dynactin 3 (p22); dynactin subunit 3; DCTN 22; p22; dynactin light chain; dynactin 3, isoform 1; dynactin complex subunit 22 kDa subunit; DCTN22; DCTN-22; MGC111190;

Entrez Gene ID

UniProt ID

Antigen Description

DCTN3 is the smallest subunit of dynactin, a macromolecular complex consisting of20subunits ranging in size from 22 to 150 kDa. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. DCTN3 is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin.

Pathway

Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Centrosome maturation, organism-specific biosystem; G2/M Transition, organism-specific biosystem; Loss of Nlp from mitotic centrosomes, organism-specific biosystem; Loss of proteins required for interphase microtubule organization??from the centrosome, organism-specific biosystem; Mitotic G2-G2/M phases, organism-specific biosystem;