Specifications
Immunogen
Recombinant full length Human DCPS produced in HEK293T cells.
Applications
Application Notes
WB: 1/2000; IHC-P: 1/150;
Target
Alternative Names
DCPS; decapping enzyme, scavenger; scavenger mRNA-decapping enzyme DcpS; HINT 5; HSL1; HSPC015; DCS-1; mRNA decapping enzyme; heat shock-like protein 1; histidine triad protein member 5; hint-related 7meGMP-directed hydrolase; homolog of C. elegans 7meGMP
Product Background
Antigen Description
Necessary for the complete degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA fragments shorter than 10 nucleotides that are produced by 3-> 5 exosome-mediated mRNA decay. Releases m7GMP. Can also degrade m7GDP to m7GMP. Has no activity towards mRNA molecules longer than 25 nucleotides.
Pathway
Deadenylation-dependent mRNA decay, organism-specific biosystem; Gene Expression, organism-specific biosystem; RNA degradation, organism-specific biosystem; RNA degradation, conserved biosystem; mRNA Decay by 3 to 5 Exoribonuclease, organism-specific biosystem;
Citations
Publication ()
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COA
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