Anti-DBR1 monoclonal antibody (DCABH-11223) Made to order

Rabbit anti-Human DBR1 monoclonal antibody for WB, ELISA

View other DBR1 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human DBR1 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
DBR1; debranching enzyme homolog 1 (S. cerevisiae); debranching enzyme (S. Cerevisiae) homolog 1; lariat debranching enzyme; RNA lariat debranching enzyme
Entrez Gene ID
UniProt ID

Product Background


Gene summary
DBR1 (Debranching RNA Lariats 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and hydrolase activity, acting on ester bonds. The protein encoded by this gene is an RNA lariat debranching enzyme that hydrolyzes 2'-5' prime branched phosphodiester bonds. The encoded protein specifically targets the bonds at the branch point of excised lariat intron RNA, converting them to linear molecules that are then degraded. This protein may also be involved in retroviral replication.
Antigen Description
The RNA lariat debranching enzyme, or DBR1, specifically hydrolyzes 2-prime-to-5-prime branched phosphodiester bonds at the branch point of excised lariat intron RNA and converts them into linear molecules. Cleaves the 2-5 phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis. Lariat debranching enzyme is a protein that in humans is encoded by the DBR1 gene. 0The function about DBR1 antigen include RNA lariat debranching enzyme activity; hydrolase activity, acting on ester bonds; metal ion binding.

Citations


Have you cited DCABH-11223 in a publication? Let us know and earn a reward for your research.

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

Customer Reviews


Write a review, share your experiences with others and get rewarded !
Product Name Cat. No. Applications Host Species Datasheet Price Add to Basket

References


Johnson, KL; Ovsyannikova, IG; et al. Identification of class IIHLA-DBR1*03-bound measles virus peptides by 2D-liquid chromatography tandem mass spectrometry. JOURNAL OF PROTEOME RESEARCH 4:2243-2249(2005).
Farragher, TM; Goodson, NJ; et al. The interaction between the hla-dbr1 shared epitope, smoking and anti-CCP antibodies is associated with high premature all cause and CVD mortality in patients with inflammatory polyarthritis. RHEUMATOLOGY 46:I2-I2(2007).

Online Inquiry

Name:
Phone: *
E-mail Address: *
Service & Products Interested: *
Project Description:
Verification Code: * Please input "diagnostics" as verification code.

Online Inquiry

  Interested in larger quantities ? request a quote!
  Protocol may be improved. Please feel free to contact us to obtain the latest version.!

Ordering Information

Payment methods we support:
Invoice / Purchase Order
Credit card

OUR PROMISE TO YOU Guaranteed product quality expert customer support

Inquiry Basket