Specifications
Immunogen
A synthetic peptide of human DARS2 is used for rabbit immunization.
Target
Alternative Names
DARS2; aspartyl-tRNA synthetase 2, mitochondrial; aspartate--tRNA ligase, mitochondrial; aspartate tRNA ligase 2; mitochondrial; FLJ10514; aspartate tRNA ligase 2, mitochondrial; aspartyl-tRNA synthetase, mitochondrial; LBSL; ASPRS; MT-ASPRS; RP3-383J4.2;
Product Background
Antigen Description
Aspartyl-tRNA synthetase (DARS) charges its cognate tRNA with aspartate during protein biosynthesis. Mammalian synthetases differ from those of prokaryotes and lower eukaryotes in that they associate as multienzyme complexes. Defects in DARS2 are a cause of leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation.
Pathway
Aminoacyl-tRNA biosynthesis, organism-specific biosystem; Aminoacyl-tRNA biosynthesis, conserved biosystem; Aminoacyl-tRNA biosynthesis, eukaryotes, organism-specific biosystem; Aminoacyl-tRNA biosynthesis, eukaryotes, conserved biosystem; Gene Expression
Citations
Publication ()
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COA
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