Anti-KRT5 monoclonal antibody, clone 27.5

Antibody Isotype

IgG2a

Clone

27.5

Species Reactivity

Human

Immunogen

Tissue/ cell preparation (cytokeratin enriched extract of feline tongue epithelium).

Conjugate

Alternative Names

KRT5; keratin 5; EBS2, epidermolysis bullosa simplex 2 Dowling Meara/Kobner/Weber Cockayne types , keratin 5 (epidermolysis bullosa simplex, Dowling Meara/Kobner/Weber Cockayne types); keratin, type II cytoskeletal 5; KRT5A; CK-5; cytokeratin-5; 58 kda

Entrez Gene ID

UniProt ID

Antigen Description

Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie., skin) and non keratinizing cells (i.e. mesothelial cells). Although not a traditional marker for endothelial cells, cytokeratins have also been found in some microvascular endothelial cells. Atleast 20 different cytokeratins (CK) in the molecular range of 40-70 kDa and isoelectric points of 5-8.5 can be identified using two dimensional gel electrophoresis. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells.

Pathway

Glucocorticoid receptor regulatory network, organism-specific biosystem;