Anti-L1-Like CAM monoclonal antibody (DMAB9544)

Mouse anti-Chicken L1-Like CAM monoclonal antibody for IHC, IP, IHC Datasheet

Bring this labeled antibody directly to your bench!

Online Inquiry Add to basket

Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
8D9
Species Reactivity
Chicken
Immunogen
chick optic nerve
Conjugate
Unconjugated

Target


Alternative Names
CALL; L1CAM2
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CHL1 (Cell Adhesion Molecule L1 Like) is a Protein Coding gene. Diseases associated with CHL1 include 3p- syndrome and large cell carcinoma with rhabdoid phenotype. Among its related pathways are Developmental Biology and L1CAM interactions. GO annotations related to this gene include protease binding. An important paralog of this gene is DSCAML1. The protein encoded by this gene is a member of the L1 gene family of neural cell adhesion molecules. It is a neural recognition molecule that may be involved in signal transduction pathways. The deletion of one copy of this gene may be responsible for mental defects in patients with 3p- syndrome. This protein may also play a role in the growth of certain cancers. Alternate splicing results in both coding and non-coding variants.
Antigen Description
Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity). Neural cell adhesion molecule L1-like protein also known as close homolog of L1 (CHL1) is a protein that in humans is encoded by the CHL1 gene. 0Neural cell adhesion molecule L1-like protein also known as close homolog of L1 (CHL1) is a protein that in humans is encoded by the CHL1 gene. CHL1 is a cell adhesion molecule closely related to the L1. In melanocytic cells CHL1 gene expression may be regulated by MITF, and can act as a helicase protein during the interphase stage of mitosis.

Citations


Have you cited DMAB9544 in a publication? Let us know and earn a reward for your research.

References


Yamanaka, H; Kobayashi, K; et al. Increase of Close Homolog of Cell Adhesion Molecule L1 in Primary Afferent by Nerve Injury and the Contribution to Neuropathic Pain. JOURNAL OF COMPARATIVE NEUROLOGY 519:1597-1615(2011).
Dong, L; Chen, SZ; et al. Single-chain variable fragment antibodies against the neural adhesion molecule CHL1 (close homolog of L1) enhance neurite outgrowth. JOURNAL OF NEUROSCIENCE RESEARCH 69:437-447(2002).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

Customer Reviews


Write a review, share your experiences with others and get rewarded !

Online Inquiry

Name
Phone *
E-mail Address *
Service & Products Interested *
Project Description
Verification Code * Please input "diagnostics" as verification code.

Online Inquiry

Order Info: Anti-L1-Like CAM monoclonal antibody

Online Inquiry
  Interested in larger quantities ? request a quote!
  Protocol may be improved. Please feel free to contact us to obtain the latest version.!
  15% off your first purchase

Ordering Information

Payment methods we support:
Invoice / Purchase Order
Credit card

OUR PROMISE TO YOU Guaranteed product quality expert customer support

Inquiry Basket