Anti-L1-Like CAM monoclonal antibody (DMAB9544)

Mouse anti-Chicken L1-Like CAM monoclonal antibody for IHC, IP, IHC Datasheet

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Host Species
Antibody Isotype
Species Reactivity
chick optic nerve


Alternative Names
Entrez Gene ID
UniProt ID

Product Background

Gene summary
CHL1 (Cell Adhesion Molecule L1 Like) is a Protein Coding gene. Diseases associated with CHL1 include 3p- syndrome and large cell carcinoma with rhabdoid phenotype. Among its related pathways are Developmental Biology and L1CAM interactions. GO annotations related to this gene include protease binding. An important paralog of this gene is DSCAML1. The protein encoded by this gene is a member of the L1 gene family of neural cell adhesion molecules. It is a neural recognition molecule that may be involved in signal transduction pathways. The deletion of one copy of this gene may be responsible for mental defects in patients with 3p- syndrome. This protein may also play a role in the growth of certain cancers. Alternate splicing results in both coding and non-coding variants.
Antigen Description
Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity). Neural cell adhesion molecule L1-like protein also known as close homolog of L1 (CHL1) is a protein that in humans is encoded by the CHL1 gene. 0Neural cell adhesion molecule L1-like protein also known as close homolog of L1 (CHL1) is a protein that in humans is encoded by the CHL1 gene. CHL1 is a cell adhesion molecule closely related to the L1. In melanocytic cells CHL1 gene expression may be regulated by MITF, and can act as a helicase protein during the interphase stage of mitosis.


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Dong, L; Chen, SZ; et al. Single-chain variable fragment antibodies against the neural adhesion molecule CHL1 (close homolog of L1) enhance neurite outgrowth. JOURNAL OF NEUROSCIENCE RESEARCH 69:437-447(2002).
Buhusi, M; Midkiff, BR; et al. Close homolog of L1 is an enhancer of integrin-mediated cell migration. JOURNAL OF BIOLOGICAL CHEMISTRY 278:25024-25031(2003).

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