Magic™ Anti-Canine Heartworm Polyclonal antibody

Symptomatic cats infected by Aelurostrongylus abstrusus show non-specific and respiratory clinical signs, often misdiagnosed as other diseases more prevalent among feline population, such as allergic respiratory disease or heartworm associated respiratory disease (HARD). Clinical signs are due to the pulmonary inflammatory response caused by the eggs shed by the adult females and the migration of the first-stage larvae up the bronchial tree. Barometric whole-body plethysmography (BWBP) is a non-invasive pulmonary function test that allows a dynamic study of breathing patterns by placing the patient within an unrestrained Plexiglas chamber. This is the first report that determines the degree of bronchoconstriction caused by A. abstrusus infection in a cat by using BWBP, showing an increase of baseline measurements of bronchoconstriction indexes (Enhanced pause and Pause) in response to severe bronchial reactivity, a consequence of the airway inflammation caused by the presence of A. abstrusus.

Evolution of pulmonary arterial and parenchymal changes as assessed with computed tomography (CT) is described in a dog experimentally infected with Dirofilaria immitis. The dog was imaged 125, 168, 216, and 402 days after infection. Initial changes during the prepatent phase of infection included enlargement of the peripheral caudal lobar pulmonary arteries and intermittent periarterial interstitial infiltrates. The changes were progressive, involving additional arteries over time, but remained mild. With the presence of adult filariae a filling defect was observed in the caudal lobar pulmonary artery using CT angiography. Recognizing thoracic CT findings associated with the prepatent phase of canine heartworm infection may be important in endemic areas.