General Notes
This product (Catalog No. DPABH-15777) is a rabbit-derived polyclonal antibody raised against human Calmodulin. This antibody exhibits cross-reactivity with Calmodulin from mouse and rat. It has been affinity purified by Protein A. Calmodulin (CaM) is a highly conserved, ubiquitous calcium-binding protein that functions as a central sensor and transducer of intracellular calcium signals in eukaryotic cells, regulating a wide array of physiological processes through interactions with diverse target proteins. Encoded by three distinct genes (CALM1, CALM2, and CALM3) in vertebrates, which produce an identical 148-amino-acid polypeptide with a molecular weight of 16.7 kDa, CaM is expressed in nearly all tissues and constitutes approximately 0.1% of total cellular protein content. Discovered in the 1970s as a heat-stable activator of phosphodiesterase, CaM exemplifies the EF-hand family of calcium sensors and plays pivotal roles in calcium-dependent signaling pathways essential for cellular homeostasis.
DPABH-15777 is suitable for use in Western blot (WB) (1:500–1:2,000), IHC (1:100–1:300), IF (immunofluorescence) (1:200–1:1,000), ELISA (1:10000) applications.
DPABH-15777 is supplied as a liquid formulation in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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