Anti-CYTH4 monoclonal antibody (DCABH-11209) Made to order

Rabbit anti-Human CYTH4 monoclonal antibody for WB, ELISA

View other CYTH4 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human CYTH4 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
CYTH4; cytohesin 4; pleckstrin homology, Sec7 and coiled coil domains 4 , pleckstrin homology, Sec7 and coiled/coil domains 4 , PSCD4; cytohesin-4; CYT4; pleckstrin homology, Sec7 and coiled-coil domains 4
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CYTH4 (Cytohesin 4) is a Protein Coding gene. Among its related pathways are Endocytosis and Phospholipase D signaling pathway. GO annotations related to this gene include lipid binding and ARF guanyl-nucleotide exchange factor activity. An important paralog of this gene is ENSG00000268465. This gene encodes a member of the PSCD family of proteins, which have an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family function as GEPs for ADP-ribosylation factors (ARFs), which are guanine nucleotide-binding proteins involved in vesicular trafficking pathways. This protein exhibits GEP activity in vitro with ARF1 and ARF5, but is inactive with ARF6. Alternatively spliced transcript variants have been found for this gene.
Antigen Description
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with both ARF1 and ARF5 but is inactive with ARF6. The structures of this gene and CYTH1 are very similar. Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP. Cytohesin-4 is a protein that in humans is encoded by the CYTH4 gene. 0The function about CYTH4 antigen include ARF guanyl-nucleotide exchange factor activity; ARF guanyl-nucleotide exchange factor activity.

Citations


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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Sendide, K; Reiner, NE; et al. Cross-talk between CD14 and complement receptor 3 promotes phagocytosis of mycobacteria: Regulation by phosphatidylinositol 3-kinase and cytohesin-1. JOURNAL OF IMMUNOLOGY 174:4210-4219(2005).
Hmama, Z; Knutson, KL; et al. Monocyte adherence induced by lipopolysaccharide involves CD14, LFA-1, and cytohesin-1 - Regulation by Rho and phosphatidylinositol 3-kinase. JOURNAL OF BIOLOGICAL CHEMISTRY 274:1050-1057(1999).

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