This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of cholic acid and chenodeoxycholic acid both of which are secreted in the bile and affect the solubility of cholesterol. This gene is unique among the cytochrome P450 genes in that it is intronless.
Pathway
Arachidonic acid metabolism; Bile acid and bile salt metabolism; Bile acid biosynthesis, cholesterol cholate; Biological oxidations; Cytochrome P45 - arranged by substrate type; Eicosanoids; Endogenous sterols; Metabolism; Metabolism of lipids and lipoproteins; Nuclear receptors in lipid metabolism and toxicity.
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