Specifications
Species Reactivity
Human; Mouse
Immunogen
CYP4F3 (NP_000887, 100 a.a. ~ 198 a.a) partial recombinant protein with GST tag. The sequence is RIFHPTYIKPVLFAPAAIVPKDKVFYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNI LKPYMKIFNESVNIMHAKWQLLASEGSARLDMFEHISLM
Target
Alternative Names
CYP4F3; cytochrome P450, family 4, subfamily F, polypeptide 3; CPF3; CYP4F; LTB4H; leukotriene-B(4) omega-hydroxylase 2; CYPIVF3; cytochrome P-450; cytochrome P450 4F3; cytochrome P450-LTB-omega; leukotriene-B4 20-monooxygenase; leukotriene B4 omega hydro
Product Background
Antigen Description
This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Three transcript variants encoding two different isoforms have been found for this gene.
Pathway
Arachidonic acid metabolism; Biological oxidations; Eicosanoids; Metabolism.
Citations
Publication ()
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COA
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