Anti-CYP2R1 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human CYP2R1 is used for rabbit immunization.

Conjugate

Alternative Names

CYP2R1; cytochrome P450, family 2, subfamily R, polypeptide 1; vitamin D 25-hydroxylase; cytochrome P450 2R1; cytochrome P450, family 2, R1; MGC4663;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor. A mutation in this gene has been associated with selective 25-hydroxyvitamin D deficiency.

Pathway

1,25-dihydroxyvitamin D3 biosynthesis, conserved biosystem; Biological oxidations, organism-specific biosystem; Cholecalciferol biosynthesis, organism-specific biosystem; Cholecalciferol biosynthesis, conserved biosystem; Cytochrome P450 - arranged by substrate type, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem;