Anti-CYP2C9 monoclonal antibody, clone 793DU6.7.3

Antibody Isotype

IgM

Clone

793DU6.7.3

Species Reactivity

Human

Conjugate

Application Notes

WB: 1:100-1600

Alternative Names

CYP2C9; CYP2C10; Cytochrome P450 2C9; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC9; Cytochrome P-450MP; Cytochrome P450 MP-4; Cytochrome P450 MP-8; Cytochrome P450 PB-1; S-mephenytoin 4-hydroxylase

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the cytochrome P450superfamily of enzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drugmetabolism and synthesis of cholesterol, steroids and other lipids.This protein localizes to the endoplasmic reticulum and itsexpression is induced by rifampin. The enzyme is known tometabolize many xenobiotics, including phenytoin, tolbutamide,ibuprofen and S-warfarin. Studies identifying individuals who arepoor metabolizers of phenytoin and tolbutamide suggest that thisgene is polymorphic. The gene is located within a cluster ofcytochrome P450 genes on chromosome 10q24.

Pathway

Arachidonate Epoxygenase / Epoxide Hydrolase; Arachidonic acid metabolism; Biological oxidations; CYP2E1 reactions; Chemical carcinogenesis; Cytochrome P450 - arranged by substrate type; Drug metabolism - cytochrome P450; Linoleic acid metabolism;