Goat anti-Human CYP2C8 polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide: KNVALTRSYIREK (Human) by a Cysteine residue linker from the internal region of Human CYP2C8 (NP_000761.3; NP_001185782.1; NP_001185783.1).

Conjugate

Alternative Names

CYP2C8; cytochrome P450, family 2, subfamily C, polypeptide 8; cytochrome P450, subfamily IIC (mephenytoin 4 hydroxylase), polypeptide 8; cytochrome P450 2C8; CPC8; P450 form 1; cytochrome P450 IIC2; cytochrome P450 MP-12; cytochrome P450 MP-20; cytochrom

Entrez Gene ID

UniProt ID

Antigen Description

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol).

Pathway

Arachidonate Epoxygenase / Epoxide Hydrolase; Arachidonic acid metabolism; Biological oxidations; Cytochrome P450 - arranged by substrate type; Drug metabolism - cytochrome P450;