Rabbit anti-Human CYP27A1 polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Recombinant fragment corresponding to a region within amino acids 154-460 of Human CYP27A1.

Conjugate

Alternative Names

CYP27A1; cytochrome P450, family 27, subfamily A, polypeptide 1; CYP27, cytochrome P450, subfamily XXVIIA (steroid 27 hydroxylase, cerebrotendinous xanthomatosis), polypeptide 1; sterol 26-hydroxylase, mitochondrial; cerebrotendinous xanthomatosis; CP27;

Entrez Gene ID

UniProt ID

Antigen Description

CYP27A1 is a member of the cytochrome P450 superfamily of enzymes. This mitochondrial protein oxidizes cholesterol intermediates as part of the bile synthesis pathway. It catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol. It also has also a vitamin D3-25-hydroxylase activity. Since the conversion of cholesterol to bile acids is the major route for removing cholesterol from the body, this protein is important for overall cholesterol homeostasis. Mutations in this gene cause cerebrotendinous xanthomatosis, a rare autosomal recessive lipid storage disease.

Pathway

Bile acid and bile salt metabolism; Bile acid biosynthesis, cholesterol =>cholate; Biological oxidations; Cytochrome P450 - arranged by substrate type;