KLH conjugated synthetic peptide derived from human CYP11A1/P450SCC: 321-420/521
Conjugate
Unconjugated
Applications
Application Notes
WB: 1:500-5000
General Notes
This product (Catalog No. DPABH-11577) is a rabbit-derived IgG polyclonal antibody raised against human CYP11A1, targeting the amino acid region 321–420 of the protein. This antibody exhibits cross-reactivity with CYP11A1 from mouse and rat. It has been affinity purified by Protein A. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. DPABH-11577 is suitable for use in Western blot (WB) (1:500–1:5,000) application. DPABH-11577 is supplied as a liquid formulation in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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