Anti-CYLD (aa 361-375) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Rat

Immunogen

Synthetic peptide: C-DSQQSKSKNPWYIDE, corresponding to internal sequence amino acids 361-375 of Mouse CYLD

Conjugate

Application Notes

Peptide ELISA: antibody detection limit dilution 1/32000. WB: Use at a concentration of 0.5 - 1.5 μg/ml. Detects a band of approximately 120 kDa (predicted molecular weight: 107 kDa).

Alternative Names

CYLD; cylindromatosis (turban tumor syndrome); ubiquitin carboxyl-terminal hydrolase CYLD; ubiquitin thioesterase CYLD; deubiquitinating enzyme CYLD; ubiquitin thiolesterase CYLD; ubiquitin-specific-processing protease CYLD; probable ubiquitin carboxyl-te

Entrez Gene ID

UniProt ID

Antigen Description

Protease that specifically cleaves Lys-63-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis. Required for normal cell cycle progress and normal cytokinesis. Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation. Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis.

Pathway

Osteoclast differentiation; RIG-I-like receptor signaling pathway; TNF-alpha NF-kB Signaling Pathway;