Recombinant fragment corresponding to Human NOX2/gp91phox aa 283-570.Sequence: ERLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKMEVGQYIFVKCPKV SKLEWHPFTLTSAPEEDFFSIHIRIVGDWTEGLFNACGCDKQEFQDAWKL PKIAVDGPFGTASEDVFSYEVVMLVGAGIGVTPFASILKSVWYKYCNNAT NLKLKKIYFYWLCRDTHAFEWFA
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.
Pathway
Adaptive Immune System; Class I MHC mediated antigen processing & presentation; Disease; Immune System
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