Anti-CXXC1 monoclonal antibody (DCABH-11172) Made to order

Rabbit anti-Human CXXC1 monoclonal antibody for WB, ELISA

View other CXXC1 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human CXXC1 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
CXXC1; CXXC finger protein 1; CXXC finger 1 (PHD domain); cpG-binding protein; CFP1; CGBP
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CXXC1 (CXXC Finger Protein 1) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Signaling by GPCR. GO annotations related to this gene include histone methyltransferase activity (H3-K4 specific) and unmethylated CpG binding. This gene encodes a protein that functions as a transcriptional activator that binds specifically to non-methylated CpG motifs through its CXXC domain. The protein is a component of the SETD1 complex, regulates gene expression and is essential for vertebrate development.
Antigen Description
Proteins that contain a CXXC motif within their DNA-binding domain, such as CXXC1, recognize CpG sequences and regulate gene expression (Carlone and Skalnik, 2001 [PubMed 11604496]). Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. CpG-binding protein (CGBP) also known as CXXC-type zinc finger protein 1 (CXXC1) or PHD finger and CXXC domain-containing protein 1 (PCCX1) is a protein that in humans is encoded by the CXXC1 gene. 0The function about CXXC1 antigen include DNA binding; contributes_to histone methyltransferase activity (H3-K4 specific); metal ion binding; protein binding; unmethylated CpG binding; zinc ion binding.
Pathway
Activation of Chaperone Genes by XBP1(S), organism-specific biosystem; Activation of Chaperones by IRE1alpha, organism-specific biosystem; Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem; Unfolded Protein Response, organism-specific biosystem.

Citations


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References


Bolivar, J; Garcia-Cozar, FJ; et al. Genomic structure and chromosome location of the human gene encoding the zinc finger autoantigen ZNF330. CYTOGENETICS AND CELL GENETICS 93:234-238(2001).

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