Anti-CXCL5 monoclonal antibody, clone 44280

Antibody Isotype

IgG1

Clone

44280

Species Reactivity

Human

Immunogen

E. coli-derived recombinant human CXCL5/ENA-78. Ala37-Asn114 Accession Number P42830

Conjugate

Application Notes

ELISA Capture: 2-8 μg/mL; ELISA Detection: 0.1-0.4 μg/mL; Flow Cyt: 2.5 μg/10⁶ cells;
We recommend the following for sandwich ELISA (Capture - Detection):
DCABY-3982 - DPABY-389

Alternative Names

CXCL5; chemokine (C-X-C motif) ligand 5; SCYB5; ENA-78; C-X-C motif chemokine 5; neutrophil-activating protein 78; neutrophil-activating peptide ENA-78; epithelial-derived neutrophil-activating protein 78; small inducible cytokine subfamily B (Cys-X-Cys),

Entrez Gene ID

UniProt ID

Antigen Description

CXCL5/Epithelial Cell-derived Neutrophil-activating Peptide (ENA-78), is a member of the CXC subfamily of chemokines. Full-length CXCL5/ENA-78 is 114 amino acids (aa) in length with a predicted molecular weight of 12 kDa. Following the removal of the signal peptide, bioactive CXCL5/ENA-78 is 78 aa in length. CXCL5/ENA-78 can be N-terminally cleaved by Cathepsin G and Chymotrypsin to CXCL5/ENA-74 (74 aa) and CXCL5/ENA-70 (70 aa), which show increased potency relative to CXCL5/ENA-78. While murine LIX was thought to be an ortholog to human CXCL5/ENA-78, genome-wide analysis and a consensus in the field suggests that human CXCL5/ENA-78 does not have a true murine ortholog. CXCL5/ENA-78 is upregulated at sites of inflammation and is expressed by multiple hematopoietic cell types, fibroblasts, endothelial cells, vascular smooth muscle cells, and adipocytes. It acts as a chemoattractant for neutrophils, has angiogenic properties, and contributes to cancer progression.

Pathway

Chemokine receptors bind chemokines; Chemokine signaling pathway; Class A/1 (Rhodopsin-like receptors); Cytokine-cytokine receptor interaction; G alpha (i) signalling events; GPCR downstream signaling; GPCR ligand binding; Peptide ligand-binding receptors